Your doctor will perform medical tests to make sure you do not have conditions that would prevent you from safely using clomiphene. Clomiphene is usually taken for 5 days, starting on the 5th day of your menstrual period. Follow your doctor's instructions. You will need to have a pelvic examination before each treatment cycle. You must remain under the care of a doctor while you are using this medicine.
You will most likely ovulate within 5 to 10 days after you take clomiphene. To improve your chance of becoming pregnant, you should have sexual intercourse while you are ovulating. Your doctor may have you take your temperature each morning and record your daily readings on a chart.
This will help you determine when you can expect ovulation to occur. In most cases, clomiphene should not be used for more than 3 treatment cycles. If ovulation occurs but you do not get pregnant after 3 treatment cycles, your doctor may stop treatment and evaluate your infertility further. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? A basal body temperature graph or other appropriate tests may help the patient and her physician determine if ovulation occurred.
Once ovulation has been established, each course of Clomiphene citrate tablets USP should be started on or about the 5th day of the cycle. Long-term cyclic therapy is not recommended beyond a total of about six cycles including three ovulatory cycles. Clomiphene citrate tablets USP is indicated only in patients with demonstrated ovulatory dysfunction who meet the conditions described below: Patients who are not pregnant.
Patients without ovarian cysts. Clomiphene citrate tablets USP should not be used in patients with ovarian enlargement except those with polycystic ovary syndrome. Pelvic examination is necessary prior to the first and each subsequent course of Clomiphene citrate tablets USP treatment. Patients without abnormal vaginal bleeding. If abnormal vaginal bleeding is present, the patient should be carefully evaluated to ensure that neoplastic lesions are not present.
Patients with normal liver function. In addition, patients selected for Clomiphene citrate tablets USP therapy should be evaluated in regard to the following: Patients should have adequate levels of endogenous estrogen as estimated from vaginal smears, endometrial biopsy, assay of urinary estrogen, or from bleeding in response to progesterone.
Reduced estrogen levels, while less favorable, do not preclude successful therapy. Primary Pituitary or Ovarian Failure. Clomiphene citrate tablets USP therapy cannot be expected to substitute for specific treatment of other causes of ovulatory failure. Endometriosis and Endometrial Carcinoma. The incidence of endometriosis and endometrial carcinoma increases with age as does the incidence of ovulatory disorders.
Endometrial biopsy should always be performed prior to Clomiphene citrate tablets USP therapy in this population. Other Impediments to Pregnancy. Impediments to pregnancy can include thyroid disorders, adrenal disorders, hyperprolactinemia, and male factor infertility. Caution should be exercised when using Clomiphene citrate tablets USP in patients with uterine fibroids due to the potential for further enlargement of the fibroids.
There are no adequate or well-controlled studies that demonstrate the effectiveness of Clomiphene citrate tablets USP in the treatment of male infertility. In addition, testicular tumors and gynecomastia have been reported in males using Clomiphene. The cause and effect relationship between reports of testicular tumors and the administration of Clomiphene citrate tablets USP is not known.
Although the medical literature suggests various methods, there is no universally accepted standard regimen for combined therapy ie, Clomiphene citrate tablets USP in conjunction with other ovulation-inducing drugs. Similarly, there is no standard Clomiphene citrate tablets USP regimen for ovulation induction in in vitro fertilization programs to produce ova for fertilization and reintroduction.
Therefore, Clomiphene citrate tablets USP is not recommended for these uses. Epub Sep Select patients with hypogonadotropic hypogonadism may respond to treatment with clomiphene citrate. To review the management of male hypogonadotropic hypogonadism HH and evaluate the efficacy of clomiphene citrate CC. Two university-based urology clinics. Ten patients referred for male infertility evaluation.
Patients were treated with either clomiphene citrate or injectable gonadotropins. Changes in seminal parameters, gonadotropin levels, serum testosterone, and pregnancy. Ten men who were evaluated for infertility were diagnosed with HH.
Eight patients were azoospermic, and two were oligospermic on presentation. Semen parameters in this group also improved, and two of the three men achieved pregnancies with CC alone. Out of the ten men actively attempting conception, four pregnancies were achieved. Three pregnancies two with CC and one with gonadotropins were in men diagnosed with adult-onset idiopathic forms of HH. Select patients with adult-onset idiopathic forms of HH may benefit from a trial of clomiphene citrate.
Use of clomiphene citrate to reverse premature andropause secondary to steroid abuse. Tan RS, Vasudevan D. To report a case of symptomatic hypogonadism induced by the abuse of multiple steroid preparations that was subsequently reversed by clomiphene. University-affiliated andrology practice within family practice clinic.
Clomiphene citrate, mg challenge for 5 days, followed by treatment at same dose for 2 months. Reversal of symptoms, normalization of T levels with LH surge, restoration of pituitary-gonadal axis.
Clomiphene citrate is used typically in helping to restore fertility in females. This represents the first case report of the successful use of clomiphene to restore T levels and the pituitary-gonadal axis in a male patient. The axis was previously shut off with multiple anabolic steroid abuse.
Idiopathic hypogonadotropic hypogonadism in a male runner is reversed by clomiphene citrate. To assess the efficacy of estrogen antagonist therapy on the function of the hypothalamic-pituitary-testicular axis in a young male runner with significant morbidity attributable to idiopathic hypogonadotropic hypogonadism.
An uncontrolled case study. The outpatient endocrinology clinic of a university tertiary referral center. A year-old male who has run 50 to 90 miles per week since 15 years of age and who presented with a pelvic stress fracture, markedly decreased bone mineral density, and symptomatic hypogonadotropic hypogonadism. Clomiphene citrate CC at doses up to 50 mg two times per day over a 5-month period. The patient experienced improved erectile function, increased testicular size and sexual hair growth, and an improved sense of well being.
Exercise-induced hypogonadotropic hypogonadism exists as a clinical entity among male endurance athletes, and CC may provide a safe and effective treatment option for males with debilitating hypogonadism related to endurance exercise.
Symptomatic late-onset hypogonadism is associated not only with a decline in serum testosterone, but also with a rise in serum estradiol. A similar situation exists in women, as birth control pills with estrogen prevent egg development and ovulation.
A clinical study at Texas Fertility Center found that Clomid caused a statistically significant increase in sperm concentration. In some cases, the increase was so great that couples who initially had no alternative other than IVF were able to conceive with IUI instead. Instead of prescribing testosterone to treat male factor infertility, physicians will prescribe Clomid, the same drug that our Austin fertility specialists give to women to help them ovulate.
In both men and women, Clomid binds to receptors in the brain to increase the production of follicle stimulating hormone, FSH, and luteinizing hormone, LH.
Three pregnancies two with CC and one with gonadotropins were in men diagnosed with adult-onset idiopathic forms of HH. Has high blood pressure, high cholesterol, sleep apnea, overweight lbs, low T levels. I mentioned it to my testosterone doc and after my T came back athe started me on testosterone shots. The bottom line is that Clomid's effects 25mg poorly understood and likely vary from individual to individual. Any help will be welcomed. David I just had my T tested, came back as Seek emergency clomiphene attention or call the Poison 25mg line at The efficacy of oral clomiphene citrate CC in the treatment of male hypogonadism and male infertility MI with low serum testosterone and normal gonadotropin levels has been reported. Lab tests, including pregnancy clomiphene, may be performed while you use Clomid, clomiphene 25mg testosterone. To testosterone sure clomiphene is safe for you, tell your doctor if you have: One year ago I stopped Androgel and testosterone dropped to It can take weeks for full effect, clomiphene 25mg testosterone.
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